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Gabriel HosuPostdoctoral Fellow, working on an experiment designed to tell us whether cytoplasmic motor components (e.g., components of the C-ring) spin at the same rate as extracellular components (e.g., the hook and filament). A cytoplasmic component, labeled with a fluorescent protein embedded in the C-ring, is bleached by an intense flash of polarized light. The fluorophores that survive are excited by a weak beam of polarized light. As the C-rings rotate, these fluorophores will fluoresce when aligned with the plane of polarization of the excitation beam. Thus, following the bleaching flash, the fluorescence emission should ring at twice the ring rotation frequency.
Selected PublicationsHosu, B.G., Mullen, S.F., Critser, J.K. and Forgacs, G. Reversible disassembly of the actin cytoskeleton improves the survival rate and developmental competence of cryopreserved mouse oocytes. PLoS ONE 3(7), e2787 (2008). Hosu, B.G., Sun, M., Marga, F., Grandbois, M. and Forgacs, G. Eukaryotic membrane tethers revisited using magnetic tweezers. Phys Biol. Apr 19; 4(2), 67-78 (2007). Hosu, B.G., Jakab, K., Banki, P., Toth, F.I. and Forgacs, G. Magnetic tweezers for intracellular applications. Rev Sci Instrum. 74(9), 4158-4163 (2003). Kovacs, E., Pologea-Moraru, R. and Hosu, B.G. Evaluation of viability of retinal photoreceptor cells by using their endogenous electrical field. Bioelectrochemistry 56(1-2), 219-21 (2002).
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Overview
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| Copyright © 2003 The Rowland Institute for Science. |
Last modified Tuesday, July 23, 2008.
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