James Foley

Member of the Photochemistry Group

Hasan, T.; Yarmush, M.; Foley, J.; Cincotta, L.; Oseroff, A., "Selective Targeting of Laser Damage with Exogenous Chromophores Coupled to Monoclonal Antibodies," 189th National Meeting of the American Chemical Society, 28 April-3 May 1985, Miami Beach, FL.

Valdes-Aguilera, O.; Kochevar, I.E.; Foley, J.; Cincotta, L., "Spectral Characterization of the Mitochondrial Dye 1,1 -(2-Ethyl-1,3-dioxolane)kryptocyanine (EDKC)," Photochem. Photobiol., 41 Suppl., (1985).

Oseroff, A.R.; Ohuoha, D.; McAuliffe, D.; Ara, G.; Shea, C.; Foley, J.; Cincotta, L., "Selective Mitochondrial Photolysis (SMPL): A New Mitochondrial Specific Photochemotherapy," Photochem. Photobiol., 41 Suppl., (1985).

Valdes-Aguilera, O.; Cincotta, L.; Foley, J.; Kochevar, I.E., "Active Oxygen Species in the Photolysis of 1,1'-(2-Ethyl-1,3-dioxolane)kryptocyanine (EDKC)," 14th Annual Meeting of the American Society for Photobiology, 22-26 June 1986, Los Angeles, CA, 48S.

Ara, G.; Aprille, J.; Foley, J.; Cincotta, L.; Oseroff, A.R., "A Kryptocyanine Dye Causes Photosensitized, Site-Specific Inhibition of Mitochondrial Electron Transport, and Alters ATP Levels and Cell Cycle Distributions," 14th Annual Meeting of the American Society for Photobiology, 22-26 June 1986, Los Angeles, CA, 49S.

Oseroff, A.R.; Ohuoha, D.; Ara, G.; McAuliffe, D.; Foley, J.; Cincotta, L., "Intramitochondrial Dyes Allow Selective in vitro Photolysis of Carcinoma Cells," Proc. Natl. Acad. Sci. USA, 83, 9729-9733, (1986).

Valdes-Aguilera, O.; Cincotta, L.; Foley, J.; Kochevar, I.E., "Photobleaching of a Cyanine Dye in Solution and in Membranes," Photochem. Photobiol., 45, 337-344, (1987).

Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Red Absorbing Benzo[a]phenoxazinium and Benzo[a]phenothiazinium Photosensitizers: in-vitro Evaluation," Photochem. Photobiol., 46, 751-758, (1987).

Oseroff, A.R.; Ara, G.; Ohuoha, D.; Aprille, J.; Bommer, J.C.; Yarmush, M.L.; Foley, J.; Cincotta, L., "Strategies for Selective Cancer Photochemotherapy: Antibody-Targeted and Selective Carcinoma Cell Photolysis," Photochem. Photobiol., 46 (1), 83-96, (1987).

Oseroff, A.; Foley, J.; Cincotta, L.; Parrish, J.A., "Light-Induced Killing of Carcinoma Cells," U.S. Patent no. 4,651,739 (1987).

Ara, G.; Cincotta, L.; Foley, J.; Hruza, G.; Anderson, R.R., "Phototoxicity of Melanoma Cells by High-Intensity Ruby Laser Radiation," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 51.

Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Red-Absorbing Benzophenoxonium and Benzophenothiazonium Photosensitizers," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 122.

Oseroff, A.R.; Ohuoha, D.; Ara, G.; Foley, J.; Cincotta, L., "Selective Carcinoma Cell Photolysis (SCCP). The Preferential Light-Induced Killing of Carcinoma Cells Due to Mitochondrial Accumulation of Cationic Dyes is Potentiated by 2-Deoxy-d-glucose (2-DG) and Hyperthermia," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 109.

Ohuoha, D.C.; Cincotta, L.; Foley, J.; Oseroff, A.R., "Enhancement of EDKC Phototoxicity by Cellular Glutathione Depleting Agents Buthionine Sulfoxine (BSO) and Diethyl Maleate (DEM)," Clayton Foundation Conference on Photodynamic Therapy, February 15-19, 1987, Los Angeles, CA, 123.

Oseroff, A.R.; Ohuoha, D.; Ara, G.; Kane, S.B.; Foley, J.; Cincotta, L., "The Carcinoma Cell-Selective Phototoxicity of EDKC is Potentiated by Hypoxia and Metronidazole," The 15th Annual Meeting of the American Society for Photobiology, June 21-25, 1987, Bal Harbour, FL, 101S.

Foley, J.W.; Cincotta, L.; Cincotta, A.H., "Structure and Properties of Novel Benzo[a]phenoxazinium Photochemotherapeutic Agents," Proceedings SPIE, 847, 90-95, (1987).

Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Novel Phenothiazinium Photosensitizers for Photodynamic Therapy," Advances in Photochemotherapy, Proceedings SPIE 997, (1988) 145-153.

Cincotta, A.H.; Cincotta, L.; Foley, J.W., "Novel Benzophenothiazinium Photosensitizers: Preliminary in-vivo Results," Photodynamic Therapy: Mechanisms II, Proceedings SPIE 1203, (1990) 202-210.

Lin, C.-W.; Shulok, J.R.; Wong, Y.; Cincotta, L.; Foley, J.W., "Uptake Retention and Phototoxicity of Cationic Phenoxazine Photosensitizers in Tumor Cells in Culture," Photodynamic Therapy: Mechanisms II, Proceedings SPIE 1203, (1990) 287-292.

Foley, J.W.; Cincotta, L., "Photo-inactivation of Cancer Cells," U.S. Patent no. 4,962,197 (1990).

Cincotta, A.H.; Cincotta, L.; Foley, J.W., "Novel Benzophenothiazines in the Photodynamic Therapy of Tumors," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York.

Foley, J.W.; Cincotta, L., "Novel Cationic Photochemotherapeutic Agents: Correlation of Singlet Oxygen Quantum Yields with Molecular Structure of Phenoxazine Derivatives," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York.

Lin, C.-W.; Shulok, J.R.; Wong, Y.K.; Cincotta, L.; Foley, J.W., "Mechanisms of Cellular Uptake and Phototoxicity of New Cationic Phenoxazine Photosensitizers," 3rd Biennial Meeting of the International Photodynamic Association (IPA), July 17-21, 1990, Buffalo, New York.

Lin, C.-W.; Shulok, J.R.; Wong, Y.; Cincotta, L.; Foley, J.W., "Uptake Retention and Phototoxicity of Cationic Phenoxazine Photosensitizers in Tumor Cells in Culture," Proceedings SPIE, 1203, 287-292, (1990).

Lin, C.-W.; Shulok, J.R.; Wong, Y.-K.; Schanbacher, C.F.; Cincotta, L.; Foley, J.W., "Photosensitization, Uptake, and Retention of Phenoxazine Nile Blue Derivatives in Human Bladder Carcinoma Cells," Cancer Res., 51, 1109-1116, (1991).

Foley, J.W.; Cincotta, L., "Evaluation of Nile Blue E Chalcogen Analogs as PDT Agents," Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Proceedings SPIE 1426, (1991) 208-215.

Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Cincotta, L.; Foley, J.W., "Nile Blue Derivatives as Lysosomotropic Photosensitizers," Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, Proceedings SPIE 1426, (1991) 216-227.

Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Cincotta, L.; Foley, J.W., "Lysosomal Localization and Mechanism of Uptake of Nile Blue Photosensitizers in Tumor Cells," Cancer Res., 51, 2710-2719, (1991).

Cincotta, L.; Foley, J.W.; Cincotta, A.H., "Phototoxicity, Redox Behavior, and Pharmacokinetics of Benzophenoxazine Analogues in EMT-6 Murine Sarcoma Cells," Cancer Res., 53, 2571-2580, (1993).

Lin, C.-W.; Shulok, J.R.; Kirley, S.D.; Bachelder, C.M.; Flotte, T.J.; Sherwood, M.E; Cincotta, L.; Foley, J.W., "Photodynamic Destruction of Lysosomes Mediated by Nile Blue Photosensitizers," Photochem. Photobiol., 58, 81-91, (1993).

Cincotta, A.H.; Lampros, L.; Cincotta, L.; Foley, J.; MacEachern, T., "Novel Benzophenoxazine Analogs Are Efficacious and Unique Photochemotherapeutic Drugs," XVII MGH Research Symposium and Poster Session, January 20, 1993.

Gut, I.G.; Redmond, R.W.; Foley, J.; Cincotta, L.; Kochevar, I.E., "A Comparative Investigation of the Photophysical Properties of Substituted Nile Blue A Derivatives," XVII MGH Research Symposium and Poster Session, January 20, 1993.

Cincotta, L.; Foley, J.W.; MacEachern, T.; Lampros, E.; Cincotta, A.H., "Novel Photodynamic Effects of a Benzophenothiazine on Two Different Murine Sacomas," Cancer Res., 54, 1249, (1994).

Cincotta, L.; Foley, J.W.; Szeto, D.L.; Cincotta, A.H., "Chronophototherapy with EtNBS for the Treatment of Solid Tumors," Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy V, Proceedings SPIE 2392, (1995) 124.

Wagner, S.J.; Skripchenko, A.; Robinette, D.; Foley, J.W.; Cincotta, L., "Factors Affecting Virus Photoinactivation by a Series of Phenothiazine Dyes," Photochemistry and Photobiology, 67, 343-349, (1998).

Frimberger, A.E.; Moore, A.S.; Cincotta, L.; Cotter, S.M.; Foley, J.W., "Photodynamic therapy of naturally occuring tumors in animals using a novel benzophenothiazine photosensitizer," Clinical Cancer Research, 4, 2207-2218, (1998).

Gloster D.; Cincotta, L.; Foley, J.W., "Design, Synthesis, and Photophysical Characterization of Novel Pentacyclic Red Shifted Azine Dyes," J. Heterocycl. Chem 36, 25-32 (1999).

Wagner SJ, Skripchenko A, Robinette D, Mallory DA, Hirayama J, Cincotta L, Foley J., "The use of dimethylmethylene blue for virus photoinactivation of red cell suspensions," Dev Biol Stand 102, 125-129 (2000).

Nikas, D.C.; Foley, J.W.; Black, P.M., "Fluorescent Imaging in a Glioma Model in Vivo," Lasers Surg Med 29, 11-17 (2001).